File:Histograms of Age of Father, Mother and Newborn - Coloring with Number of mutations.png

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English: Parents’ age distribution with number of de novo mutations in their offsprings. (a) The distribution of father's ages at conception (in years). (b) The distribution of mother's ages at conception (in years). (c) The distribution of gestational age for the newborns (in weeks). The colours in each bar in the histograms indicate the proportion of newborns with each number of DNMs in each of the five equally sized bins.


Among the set of 693 mother–father–newborn trios, the ages of the fathers at conception ranged from 17 to 63 years, with a mean of 33.4 years. Twenty-four (3.5%) of the fathers were older than 45 years, extending by 18 years the age range for the statistical model from previously reported whole-genome studies2, 3. The ages of the mothers ranged from 17 to 43 years with a mean of 31.2 years. The gestational age of the newborns ranged from 23 to 42 weeks with a mean of 37.2 weeks.
Date Published 19 January 2016
Source Wong, W. S. W. et al. New observations on maternal age effect on germline de novo mutations. Nat. Commun. 7:10486 doi: 10.1038/ncomms10486 (2016). http://www.nature.com/ncomms/2016/160119/ncomms10486/full/ncomms10486.html
Author Wendy S. W. Wong, Benjamin D. Solomon, Dale L. Bodian, Prachi Kothiyal, Greg Eley, Kathi C. Huddleston, Robin Baker, Dzung C. Thach, Ramaswamy K. Iyer, Joseph G. Vockley & John E. Niederhuber
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Average number of de novo mutations by chromosome
De novo mutations by age of father and mother
Distribution of the ratios between number of DNMs of maternal origin and paternal origin

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current08:16, 23 September 2016Thumbnail for version as of 08:16, 23 September 20161,544 × 610 (171 KB)Was a bee (talk | contribs)== {{int:filedesc}} == {{Information |Description={{en|1= Parents’ age distribution with number of de novo mutations in their offsprings. ('''a''') The distribution of father's ages at conception (in years). ('''b''') The distribution of mother's age...

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