File:HMB biosynthesis and metabolism diagram.png
Original file (877 × 654 pixels, file size: 63 KB, MIME type: image/png)
Captions
Summary
[edit]DescriptionHMB biosynthesis and metabolism diagram.png |
English: This image is a screenshot of en:Template:Leucine metabolism in humans; it is intended for external (i.e., off-wiki) use.
This illustration depicts the primary metabolic pathways of L-leucine in humans which involve β-hydroxy β-methylbutyrate and isovaleryl-CoA as metabolites.[1][2][3][4][5] A third human metabolic pathway – which accounts for a very small fraction of leucine metabolism and involves the conversion of L-leucine into β-leucine by leucine aminomutase[3] – is not depicted in this image. Of the two major pathways, L-leucine is mostly metabolized into isovaleryl-CoA, while only about 5% is metabolized into HMB.[1][2][3]
|
Date | |
Source | Own work |
Author | Seppi333 |
Other versions |
Other high-quality versions of this diagram: ■ SVG version with labels: File:HMB biosynthesis and metabolism diagram.svg (coming soon) ■ SVG version without labels: File:HMB biosynthesis and metabolism diagram - no labels.svg Low-quality versions of this diagram that contain duplicated pathways: ■ Labeled JPG version with duplicate pathways: File:ISSN HMB statement Fig 1.jpg ■ Unlabeled JPG version with duplicate pathways: File:ISSN HMB statement Fig 1 - no labels.jpg |
Licensing
[edit]- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Annotations InfoField | This image is annotated: View the annotations at Commons |
This reaction is catalyzed by an unknown thioesterase enzyme.
References:
■ PMID 21918059
■ KEGG reaction R10759
In healthy individuals, the conversion of MC-CoA to HMB-CoA is a relatively minor route of HMB biosynthesis.
During biotin deficiency, MC-CoA metabolism is diverted to this pathway because the MC-CoA carboxylase enzyme requires biotin as a cofactor. Consequently, on average, individuals experiencing biotin deficiency have higher plasma HMB concentrations relative to healthy individuals.
This pathway is the primary route of HMB biosynthesis; roughly 5% (2–10% range) of dietary leucine is metabolized along this pathway.
KIC-dioxygenase, also known as 4-hydroxyphenylpyruvate dioxygenase, is a cytosolic liver enzyme.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 07:29, 7 February 2018 | 877 × 654 (63 KB) | Seppi333 (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on ja.wikipedia.org
- Usage on pl.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Horizontal resolution | 37.79 dpc |
---|---|
Vertical resolution | 37.79 dpc |