File:Good P+T.png
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Captions
Captions
Comparative visualization of genetic variant selection strategies employed in the derivation of polygenic scores.
Summary
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| Description |
English: Left (Pruning/Clumping): Genetic variants are grouped into linkage disequilibrium (LD) blocks, each represented by unique color shades. Within each LD block, the variant exhibiting the highest effect size is denoted by a red star, highlighting the pruning selection criteria based on maximal association strength. Right (Thresholding): All genetic variants are plotted in terms of their -log10 transformed p-values. Variants surpassing a significance threshold (indicated by the dashed horizontal line) are emphasized in blue, denoting their retention for polygenic score calculation. This threshold, set at p=0.05, exemplifies a conventional approach to minimize inclusion of variants exerting null or negligible effects. However, typically much larger p-values, such as 0.9 or 1.0, are used for optimal prediction results. |
| Date | |
| Source | Own work |
| Author | Chamaemelum |
Licensing
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I, the copyright holder of this work, hereby publish it under the following license:
 
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This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. |
| The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:33, 11 August 2023 | | 1,440 × 600 (71 KB) | Chamaemelum (talk | contribs) | Uploaded own work with UploadWizard |
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