File:Gastrulation gives rise to the three primary germ layers of the mouse embryo proper..png
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| Description | Figure 3. Gastrulation gives rise to the three primary germ layers of the embryo proper. The inner cell mass (ICM) is a pluripotent population of cells that arises between 3.5 and 4.5 dpc within the blastocyst. By 5.5 dpc, the ICM differentiates into the multipotent extraembryonic primitive endoderm lineage and a second pluripotent population, the primitive ectoderm. At 6.5 dpc, the primitive ectoderm undergoes gastrulation in response to various signals including Nodal, resulting in a subset of cells undergoing an epithelialto-mesenchymal transition (EMT), allowing them to ingress through the primitive streak and form the definitive mesoderm and definitive endoderm germ layers. The remaining primitive ectoderm cells (which see little or no Nodal) do not move through the streak and give rise to the definitive ectoderm germ layer, which further differentiates into the surface ectoderm and neurectoderm in response to the presence and absence of BMP4 signaling, respectively. Key: CNS, central nervous system; ENS, enteric nervous system; GIT, gastrointestinal tract (epithelial lining); PNS, peripheral nervous system; RT, respiratory tract (epithelial lining). |
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| Source | https://www.researchgate.net/figure/Gastrulation-gives-rise-to-the-three-primary-germ-layers-of-the-embryo-proper-The_fig2_334407321 https://www.researchgate.net/publication/334407321_Modeling_Mammalian_Commitment_to_the_Neural_Lineage_Using_Embryos_and_Embryonic_Stem_Cells Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells. July 2019. Frontiers in Physiology 10 DOI:10.3389/fphys.2019.00705 |
| Author | Rachel A. Shparberg, Hannah J. Glover, Michael B. Morris |
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Copyright © 2019 Shparberg, Glover and Morris. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 21:07, 29 April 2024 | | 1,209 × 806 (202 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. Gastrulation gives rise to the three primary germ layers of the embryo proper. The inner cell mass (ICM) is a pluripotent population of cells that arises between 3.5 and 4.5 dpc within the blastocyst. By 5.5 dpc, the ICM differentiates into the multipotent extraembryonic primitive endoderm lineage and a second pluripotent population, the primitive ectoderm. At 6.5 dpc, the primitive ectoderm undergoes gastrulation in response to various signals including N... |
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