File:Functions of FGF signalling in the three-dimensional retinal development.jpg
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| Description | Figure 4. Functions of FGF signalling in the three-dimensional retinal development. (a) Schematic representation of the mouse E11.5 optic cup denotes the choroid fissure in green, the NR in blue and the OD in purple. D, dorsal; V, ventral. (b) (i) Cross-section of (a) illustrates the gradient activity of pERK in the establishment of the RPE, CM, NR and OD. LV, lens vesicle. (ii) FGF signalling promotes the neural retinal fate by activating the transcription factor Pax2 (green/purple) and Chx10 (green/blue) while also inhibiting the expression of the RPE specific factor Mitf (orange). |
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| Source | https://royalsocietypublishing.org/doi/10.1098/rsob.210265 Neoklis Makrides, Qian Wang, Chenqi Tao, Samuel Schwartz and Xin Zhang. Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development |
| Author | Neoklis Makrides, Qian Wang, Chenqi Tao, Samuel Schwartz and Xin Zhang DOI:https://doi.org/10.1098/rsob.210265 |
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© 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
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| current | 19:03, 16 September 2024 | | 1,627 × 1,008 (167 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 4. Functions of FGF signalling in the three-dimensional retinal development. (a) Schematic representation of the mouse E11.5 optic cup denotes the choroid fissure in green, the NR in blue and the OD in purple. D, dorsal; V, ventral. (b) (i) Cross-section of (a) illustrates the gradient activity of pERK in the establishment of the RPE, CM, NR and OD. LV, lens vesicle. (ii) FGF signalling promotes the neural retinal fate by activating the transcription factor P... |
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