File:Fphar-14-1294966-g002-Photoroom (1).png
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Fphar-14-1294966-g002-Photoroom_(1).png (582 × 476 pixels, file size: 175 KB, MIME type: image/png)
File information
Structured data
Captions
Captions
Enfuvirtide
Summary
[edit]DescriptionFphar-14-1294966-g002-Photoroom (1).png |
English: FIGURE 2. Host mechanism of HIV-1 infection and targets of anti-HIV-1 drugs. HIV infection of cells involves five processes: adsorption, invasion, decapitation, synthesis, and assembly. The viral glycoprotein spike gp120 binds to CD4 on the host cell surface. Under the mediation of CCR5 or CXCR4, the virus fuses with the host cell membrane. In this process, fostemsavir tromethamine (Wang et al., 2021) is active on gp120, enfuvirtide (Monteiro et al., 2021; Yeruva and Lee, 2022) and albuvirtide (Chong et al., 2012) act on gp41 6-HB, maraviroc, plerixafor, and salmeterol function on CCR5 or CXCR4 (Woollard and Kanmogne, 2015; Mirza et al., 2020; Wang et al., 2020), and ibalizumab (Bettiker et al., 2018) acts on CD4 receptor in host cells. All of these drugs’ act to prevent viral adsorption or invasion. When viral RNA is reverse-transcribed to form RNA-DNA and enters the host cell nucleus, integrase inhibitors such as cabotegravir sodium prevent its integration into host DNA. Even if viral genetic material is already successfully integrated, foscarnet sodium (Devianne-Garrigue et al., 1998) and resveratrol (Zhang et al., 2009) can prevent its transcription and translation to form viral proteins, respectively. Impressively, the capsid protein inhibitor lenacapavir and GSK878 are now available and efficiently blocks viral infection of host cells (Segal-Maurer et al., 2022). Created with BioRender.com. |
Date | |
Source | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1294966/full |
Author | Peng Y, Zong Y, Wang D, Chen J, Chen ZS, Peng F, Liu Z. |
Licensing
[edit]![w:en:Creative Commons](https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/90px-CC_some_rights_reserved.svg.png)
![attribution](https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/24px-Cc-by_new_white.svg.png)
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 04:00, 16 April 2024 | ![]() | 582 × 476 (175 KB) | Doc James (talk | contribs) | Cropped 23 % horizontally, 10 % vertically using CropTool with precise mode. |
18:36, 13 April 2024 | ![]() | 754 × 529 (233 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Peng Y, Zong Y, Wang D, Chen J, Chen ZS, Peng F, Liu Z. from https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1294966/full with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Horizontal resolution | 37.78 dpc |
---|---|
Vertical resolution | 37.78 dpc |
File change date and time | 04:00, 16 April 2024 |
Hidden category: