File:Fnmol-07-00048-g001 (14400966226).jpg

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Source: Front. Mol. Neurosci., 27 May 2014 | doi:10.3389/fnmol.2014.00048 Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders Sarah van Veen, Danny M. Sørensen, Tine Holemans, Henrik W. Holen, Michael G. Palmgren and Peter Vangheluwe

Figure 1. Phyologenetic tree of the human P-type ATPases. Phylogenetic tree based on the core protein sequences of 137 animal homologues of the 36 human P-type ATPase isoforms. ATP13A2 homologues were obtained from the database Homologene <a href="https://www.ncbi.nlm.nih.gov/homologene" rel="nofollow">www.ncbi.nlm.nih.gov/homologene</a>. Core protein sequences were generated according to the methodology described in Axelsen and Palmgren (1998). The 36 human P-type ATPases are indicated. Of note, only animal isoforms are depicted, so the P3A-type ATPases, which are uniquely found in fungi and plants and the small class of bacterial Mg+-ATPases of the P3B group and bacterial pumps belonging to P1A are not represented. The phylogenetic tree was rendered using <a href="http://www.phylogeny.fr" rel="nofollow">www.phylogeny.fr</a> (Dereeper et al., 2008, 2010).
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This image was originally posted to Flickr by phylofigures at https://flickr.com/photos/123636286@N02/14400966226. It was reviewed on 19 December 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-2.0.

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