File:Fluorescence Imaging 07.jpg
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Deutsch: Die Anreicherung von STL-6014, einem Bakteriochlorophyll (BChl), das mit einer RGD-Sequenz konjugiert wurde, im nekrotischen Gewebe eines orthotopen Brustkrebstumors vom Typ MDA-MB-231-RFP (rotfluoreszierendes Protein), der in CD-1-Nacktmäuse implantiert wurde. 15 mg/kg KGW STL-6014 wurden intravenös appliziert. Zeile A: Fusionsbild Tageslicht-/"NIR"-Aufnahme (575-650 nm) der Maus zeigt den gesamten rotfluoreszierenden Tumor English: Correlation between necrotic volumes and STL-6014 accumulation in MDA-MB-231-RFP tumors. CD-1 nude, female mice bearing MDA-MB-231-RFP tumors orthotopically grafted to the mammary fat pad were intravenously injected with STL-6014 (15 mg/kg). Images of large (animals #1,2) and small (animals #3,4) tumors were taken at seven and five days, respectively, post-injection. (a) Red fluorescence protein (RFP) fluorescence images indicate tumor size and location. (b and c) Near infrared (NIR) fluorescence images demonstrating STL-6014 distribution both in vivo and after dissection, respectively. (d) Color photos. (e) Tissue sections of the tumor center stained with hematoxylin and eosin. |
| Date | published 24 May 2010 |
| Source | Liat Goldshaid, Efrat Rubinstein, Alexander Brandis, Dadi Segal, Noa Leshem, Ori Brenner, Vyacheslav Kalchenko, Doron Eren, Tamar Yecheskel, Yoseph Salitra, Yoram Salomon and Avigdor Scherz: Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors. In: Breast Cancer Research 2010, 12:R29doi:10.1186/bcr2579 Open Access |
| Author | Liat Goldshaid, Efrat Rubinstein, Alexander Brandis, Dadi Segal, Noa Leshem, Ori Brenner, Vyacheslav Kalchenko, Doron Eren, Tamar Yecheskel, Yoseph Salitra, Yoram Salomon and Avigdor Scherz |
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| current | 17:43, 23 June 2010 | | 2,008 × 2,576 (1,005 KB) | Kuebi (talk | contribs) | {{Information |Description={{de|Die Anreicherung von STL-6014, einem Bakteriochlorophyll (BChl), das mit einer RGD-Sequenz konjugiert wurde, im nekrotischen Gewebe eines orthotopen Brustkrebstumors vom Typ MDA-MB-231-RFP (rotfluoreszierendes Protein), der |
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