File:Fimmu-09-01581-g005.jpg
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[edit]DescriptionFimmu-09-01581-g005.jpg |
English: Coordination of viral ribonucleoprotein (vRNP) assembly and trafficking to the plasma membrane. Upon entry into the host cell nucleus, (i) the vRNP-associated viral polymerase transcribes the viral mRNAs. (ii) The mRNAs are either directly, or after alternative splicing, exported for translation by cytosolic ribosomes. (iii) Newly synthesized viral polymerase subunits (PA, PB1, and PB2) and nucleoprotein (NP) are imported back into the nucleus. (iv) Due to the inefficient dinucleotide priming, the vRNP-associated viral polymerase also infrequently transcribes complimentary RNA (cRNA) copies that assemble into cRNPs via (v) binding of a newly synthesized viral polymerase (PA, PB1, and PB2) and NP. (vi) The polymerase transcribes viral RNA (vRNA) copies from the positive strand in the cRNPs and these assemble into vRNPs by (vii) association with a new viral polymerase (PA, PB1, and PB2) and NP. Once assembled, the new vRNPs can (viii) transcribe additional viral mRNAs, (ix) transcribe new cRNA copies, or (x) associate with the newly synthesized viral proteins M1 and NS2 to facilitate the recruitment of CRM1, which (xi) mediates the nuclear export of the vRNP. (xiia) Once exported, the vRNPs then associate with Rab11 that assists in the trafficking of the vRNPs toward the cell surface. The vRNP trafficking either occurs by Rab11-containing vesicles associated with microtubules or (xiib) through Rab11 located in the modified endoplasmic reticulum (ER) membranes. How the vRNPs reach the budding site at the plasma membrane is currently not known. |
Date | |
Source | https://www.frontiersin.org/articles/10.3389/fimmu.2018.01581/full |
Author | imageDan Dou, Rebecca Revol, Henrik Östbye, Hao Wang, and Robert Daniels |
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current | 06:45, 7 August 2020 | 1,192 × 607 (317 KB) | Guest2625 (talk | contribs) | Uploaded a work by imageDan Dou, Rebecca Revol, Henrik Östbye, Hao Wang, and Robert Daniels from https://www.frontiersin.org/articles/10.3389/fimmu.2018.01581/full with UploadWizard |
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Orientation | Normal |
Horizontal resolution | 500 dpi |
Vertical resolution | 500 dpi |
Software used | Adobe Photoshop CS5 Windows |
File change date and time | 13:30, 17 July 2018 |
Color space | sRGB |
Date and time of digitizing | 22:05, 11 July 2018 |
Date metadata was last modified | 19:00, 17 July 2018 |
Unique ID of original document | uuid:9E3E5C9A8C81DB118734DB58FDDE4BA7 |
IIM version | 39,338 |