File:Fig-2-a-Illustration-of-drug-delivery-of-the-PEG-CPT-NRs.gif
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English: Fig. 2 a Illustration of drug delivery of the PEG-CPT NRs. Once intravenously administrated, the PEG-CPT NRs were accumulated at the tumor site by the enhanced permeability and retention (EPR) effect-mediated passive tumor-targeting mechanism, were internalized by the tumor cells endocytosis, released CPT in a sustained manner, and intracellularly delivered CPT to the nucleus. b The MTX-PEG-CPT NRs with MTX self-targeting ligand enter tumor cells by FA receptor-mediated endocytosis and released both CPT and MTX anticancer drugs in tumor cells to be, respectively, delivered to nucleus and cytoplasm (CPT binds to DNA in the nucleus, and MTX binds to DHFR enzyme in the cytoplasm) for self-targeted multi-drug co-delivery and combination cancer therapy |
| Date | |
| Source | Fuqiang Guo, Zhongxiong Fan, Jinbin Yang, Yang Li, Yange Wang, Hai Zhao, Liya Xie, Zhenqing Hou. "A Comparative Evaluation of Hydroxycamptothecin Drug Nanorods With and Without Methotrexate Prodrug Functionalization for Drug Delivery ," Nanoscale Research Letters doi:10.1186/s11671-016-1599-y |
| Author | Fuqiang Guo, Zhongxiong Fan, Jinbin Yang, Yang Li, Yange Wang, Hai Zhao, Liya Xie, Zhenqing Hou |
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
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