File:FMRI Dynamic Resting-State Functional Connectivity effects of DMT.jpg
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[edit]DescriptionFMRI Dynamic Resting-State Functional Connectivity effects of DMT.jpg |
English: "Dynamics changes in brain RSFC under DMT. (A, Left) Areas showing a significant association between real-time intensity ratings and dynamic global functional connectivity (GFC) for DMT minus placebo (P < 0.05, FDR corrected). (A, Middle) Dynamic effects of DMT versus placebo on network GFC, showing significant increases in GFC for DMN/FP/SAL networks—all associated with the TOP of the brain’s principal functional gradient, as well as the LIM network (*P < 0.05, **P < 0.01, ***P < 0.001; FDR corrected). (A, Right) Pairwise functional connectivity (FC) matrix representing the association between intensity ratings and dynamic functional connectivity (significant links are highlighted in the lower diagonal; FDR corrected). (B) Areas showing a significant association between DMT plasma levels and regional GFC, network GFC, and pairwise FC (FDR corrected). (C, Left) Regional GFC across time for placebo, DMT, and (C, Right) DMT minus placebo, overlayed with reported average intensity ratings (±SEM). Black boxes highlight epochs where changes in network GFC are statistically significant (cluster corrected, P < 0.05). (D) Average (DMT—placebo) pairwise FC matrices for the first seven minutes following DMT/placebo administration. (E) A significant association was found between 5-HT2AR density maps and dynamic GFC (representing beta values of the relationship between GFC and intensity ratings). (Networks: VIS = visual; SM = somatomotor; DAN = dorsal attentional; SAL = ventral attentional/salience; LIM = limbic; FP = frontoparietal; DMN = default mode; SC = subcortical regions; TOP = transmodal association pole)." |
Date | |
Source | https://www.pnas.org/doi/10.1073/pnas.2218949120 |
Author | Authors of the study: Christopher Timmermann https://orcid.org/0000-0002-2281-377X c.timmermann-slater15@imperial.ac.uk, Leor Roseman, Sharad Haridas, Fernando E. Rosas https://orcid.org/0000-0001-7790-6183, Lisa Luan, Hannes Kettner, Jonny Martell https://orcid.org/0000-0002-4194-7669, David Erritzoe https://orcid.org/0000-0002-7022-6211, Enzo Tagliazucchi, Carla Pallavicini, Manesh Girn, Andrea Alamia https://orcid.org/0000-0001-9826-2161, Robert Leech https://orcid.org/0000-0002-5801-6318, David J. Nutt https://orcid.org/0000-0002-1286-1401, and Robin L. Carhart-Harris |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 10:46, 5 May 2023 | 3,995 × 2,973 (2.35 MB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Christopher Timmermann https://orcid.org/0000-0002-2281-377X c.timmermann-slater15@imperial.ac.uk, Leor Roseman, Sharad Haridas, Fernando E. Rosas https://orcid.org/0000-0001-7790-6183, Lisa Luan, Hannes Kettner, Jonny Martell https://orcid.org/0000-0002-4194-7669, David Erritzoe https://orcid.org/0000-0002-7022-6211, Enzo Tagliazucchi, Carla Pallavicini, Manesh Girn, Andrea Alamia https://orcid.org/0000-0001-9826-2161, Robert Leech https://orcid.org/0... |
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Horizontal resolution | 600 dpi |
Vertical resolution | 600 dpi |
Color space | Uncalibrated |
Image width | 3,995 px |
Image height | 2,973 px |
Date metadata was last modified | 19:04, 17 March 2023 |
File change date and time | 19:04, 17 March 2023 |
Date and time of digitizing | 20:30, 25 February 2023 |
Software used | Adobe Illustrator 26.3 (Windows) |
Unique ID of original document | uuid:5D20892493BFDB11914A8590D31508C8 |
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