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English: FIGURE 3.

Relationships between 11C-(R)-PK11195 BPND and neuropsychologic symptoms in CFS/ME patients. Top row: Statistical parametric maps of correlations between 11C-(R)-PK11195 BPND in amygdala (A), hippocampus (B), and thalamus (C) and cognitive impairment, depression, and pain scores, respectively. Anatomic locations were mapped on template coronal brains. Bottom row: Scatterplots of 11C-(R)-PK11195 BPND in amygdala (−22, −2, 14) and cognitive impairment score (A), 11C-(R)-PK11195 BPND in hippocampus (26, −14, −16) and depression (CES-D) score (B), and 11C-(R)-PK11195 BPND in thalamus (−10, −18, 8) and pain score (C). Pearson coefficient value (r) and P value are shown for each relation. Scales show t values.

In the CFS/ME group, the SPM correlation analysis revealed that 11C-(R)-PK11195 BPND in the amygdala was positively correlated with cognitive impairment score (Fig. 3A), 11C-(R)-PK11195 BPND in the hippocampus was positively correlated with CES-D score (Fig. 3B), and 11C-(R)-PK11195 BPND in the thalamus tended to be correlated positively with pain score (voxel level, P < 0.005; cluster level, P > 0.05; Fig. 3C). There were no other correlations between 11C-(R)-PK11195 BPND in any brain regions and other parameters (age, duration of disease, VAS score of fatigue sensation, score of Chalder fatigue scale, or cytokine concentration).[1]
Date
Source http://jnm.snmjournals.org/content/55/6/945.long
Author

Yasuhito Nakatomi, Kei Mizuno, Akira Ishii, Yasuhiro Wada, Masaaki Tanaka, Shusaku Tazawa, Kayo Onoe, Sanae Fukuda, Joji Kawabe, Kazuhiro Takahashi, Yosky Kataoka, Susumu Shiomi, Kouzi Yamaguti, Masaaki Inaba, Hirohiko Kuratsune and Yasuyoshi Watanabe

This research was originally published in JNM. Author(s). Title. J Nucl Med. 2014;vol:55-no.6 945-950. © SNMMI.

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  1. Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study - This research was originally published in JNM. Author(s). Title. J Nucl Med. 2014;vol:55-no.6 945-950. © SNMMI.

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