File:Extreme organ agers are widespread in the population.webp
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From the study "Organ aging signatures in the plasma proteome track health and disease"
Summary
[edit]DescriptionExtreme organ agers are widespread in the population.webp |
English: "a, Extreme agers were defined as individuals with a 2-standard deviation increase or decrease in at least one age gap. 23% of the individuals (n = 5,676) across the four cohorts were identified as extreme agers. To visualize all extreme agers, age gaps were denoised by setting values below absolute z-score of 2 to zero. Denoised age gaps are shown in the heatmap. b, Extreme ageotypes were defined based on kmeans clustering of individuals based on their denoised age gaps. The mean z-scored age gap per ageotype is shown. c, The percentage of extreme agers is shown across all cohorts. d, A cross-cohort meta-analysis of associations (logistic regression) between extreme ageotypes versus diagnosis of 9 major age-related diseases annotated in at least 2 independent cohorts. Log odds ratios and significance are shown. P-values were Benjamini-Hochberg FDR-corrected. The strongest associations per disease are highlighted with black borders. (See ST9). e, A cross-cohort meta-analysis of associations (linear regression) between organ age gaps versus diagnosis of 9 major age-related diseases annotated in at least 2 independent cohorts. Disease covariate effects and significance are shown. P-values were Benjamini Hochberg FDR-corrected. The strongest associations per disease are highlighted with black borders. (See ST10). Asterisks represent q-value thresholds: *q < 0.05; **q < 0.01; ***q < 0.001."
It is one of the studies briefly featured in 2023 in science |
Date | |
Source | https://www.nature.com/articles/s41586-023-06802-1 |
Author | Authors of the study: Hamilton Se-Hwee Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Yagmur Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Menghan Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Guen, Taylor M. Maurer, Michael Haney, Andrew C. Yang, Zihuai He, Michael D. Greicius, Katrin I. Andreasson, Sanish Sathyan, Erica F. Weiss, Sofiya Milman, Nir Barzilai, Carlos Cruchaga, Anthony D. Wagner, Elizabeth Mormino, Benoit Lehallier, Victor W. Henderson, Frank M. Longo, Stephen B. Montgomery & Tony Wyss-Coray |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 13:37, 5 March 2024 | ![]() | 2,120 × 1,744 (223 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Hamilton Se-Hwee Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Yagmur Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Menghan Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Guen, Taylor M. Maurer, Michael Haney, Andrew C. Yang, Zihuai He, Michael D. Greicius, Katrin I. Andreasson, Sanish Sathyan, Erica F. Weiss, Sofiya Milman, Nir Barzilai, Carlos Cruchag... |
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