File:Elife-24149-fig5-v2.jpg
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Summary
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| Description |
English: The interface between TMD0 and the N-terminal segment of L0 in SUR1 with Kir6.2.
(A) Overall structure of the interface region, with TMD0 in orange, Kir6.2 in blue, and L0 in lavender. ECL: extracellular loop; ICL: intracellular loop; IF helix: interfacial (slide) helix. (B and C) Detailed view of the region boxed in red in (A) shown in ribbon (B) and surface (C) representations. ATP is docked as in Figure 3 and PIP2 was docked hypothetically using PIP2 bound Kir3.2 and Kir2.2 structures for placement. (D) A side view of the ICL2 showing close interactions with the Kir6.2 IF helix. E128 and F132, mutation of which alters channel Po and ATP sensitivity, are highlighted. (E) A top-down view of this region with both docked ATP (in the back) and PIP2 in view. |
| Date | |
| Source |
eLife 2017;6:e24149 doi: 10.7554/eLife.24149 https://elifesciences.org/articles/24149 |
| Author | Gregory M Martin Craig Yoshioka Emily A Rex Jonathan F Fay Qing Xie Matthew R Whorton James Z Chen Show-Ling Shyng |
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| current | 18:47, 16 March 2018 | | 3,566 × 4,124 (1.66 MB) | Buruneng (talk | contribs) | User created page with UploadWizard |
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