File:Elife-24149-fig3-v2.jpg
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Summary
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| Description |
English: Kir6.2 in a closed conformation.
(A) Cryo-EM density map of Kir6.2 at 5.1 Å resolution. (B) Density of M1 and M2. Residues with clear side chain density are labeled. (C) A central slice through the density highlighting the ion permeation pathway. (D) View of the inner helix gate (F168) looking down the pore from the extracellular side. Kir3.2 apo (yellow, PDB ID: 3SYO) and Kir3.2-R201A+PIP2 (red, 3SYQ) structures were aligned to the region surrounding the gate. (E) Comparison of G-loop conformations of Kir6.2 and Kir3.2 (3SYO and 3SYQ) by alignment of the cytoplasmic domain; same coloring as in (D). The distance shown in (D) and (E) is between the main chains; the constriction should be even narrower due to side chains that should be protruding into the pore, as is seen in homolgous structures. Density depictions contoured to 2.5σ in (B, D, E). |
| Date | |
| Source |
eLife 2017;6:e24149 doi: 10.7554/eLife.24149 https://elifesciences.org/articles/24149 |
| Author | Gregory M Martin Craig Yoshioka Emily A Rex Jonathan F Fay Qing Xie Matthew R Whorton James Z Chen Show-Ling Shyng |
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