File:Early ectodermal patterning at the anterior epiblast.jpg
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| Description | Figure 1. Early ectodermal patterning at the anterior epiblast. Although the ectodermal patterning varies significantly across chordates, and even within amniotes, we illustrate, here, the key stages of ectodermal patterning most faithful to amniote development. The medial epiblast begins to exhibit molecular differences compared to the surrounding tissue, with the medial region expressing pre-neural/neural (salmon) markers and lateral (blue) region with predominantly non-neural/epidermal gene expression. At the initial stages of gastrulation, the transitional zone between the neural and non-neural ectoderm, called the neural plate border (yellow), becomes more defined. By the early stages of neurulation, two distinct spatially segregated populations of cells can be detected at the border region – pre-placodal ectoderm laterally (purple) and neural crest cell progenitors medially (green). Although much remains uncertain about the roles and timing of WNT, BMP, and FGF signaling pathways and associated gene-regulatory networks during the early ectodermal patterning, a general consensus of the signaling levels and classic spatially distinct markers are indicated below the epiblast cartoons. Additionally, the asymmetric WNT signaling along the anterior-posterior axis and, subsequently, key molecular expression differences are also presented on the right-most panel. |
| Date | |
| Source | https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.608880/full Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives. Front. Physiol. 11:608880. doi: 10.3389/fphys.2020.608880 |
| Author | Thawani A and Groves AK |
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© 2020 Thawani and Groves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 09:13, 9 June 2024 | | 1,168 × 724 (442 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 1. Early ectodermal patterning at the anterior epiblast. Although the ectodermal patterning varies significantly across chordates, and even within amniotes, we illustrate, here, the key stages of ectodermal patterning most faithful to amniote development. The medial epiblast begins to exhibit molecular differences compared to the surrounding tissue, with the medial region expressing pre-neural/neural (salmon) markers and lateral (blue) region with predominant... |
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