File:Dsx splicing.jpg

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file (876 × 499 pixels, file size: 83 KB, MIME type: image/jpeg)

Captions

Captions

Add a one-line explanation of what this file represents
This biology image could be re-created using vector graphics as an SVG file. This has several advantages; see Commons:Media for cleanup for more information. If an SVG form of this image is available, please upload it and afterwards replace this template with {{vector version available|new image name}}.


It is recommended to name the SVG file “Dsx splicing.svg”—then the template Vector version available (or Vva) does not need the new image name parameter.

Summary

[edit]
Description
English: Alternative splicing of Drosophila dsx gene.

Pre-mRNAs from the D. melanogaster gene dsx contain 6 exons. In males, exons 1,2,3,5,and 6 are joined to form the mRNA, which encodes a transcriptional regulatory protein required for male development. In females, exons 1,2,3, and 4 are joined, and a polyadenylation signal in exon 4 causes cleavage of the mRNA at that point. The resulting mRNA is a transcriptional regulatory protein required for female development[1].

This is an example of exon skipping alternative splicing. The intron upstream from exon 4 has a weak-consensus polypyrimidine tract, to which U2AF proteins bind poorly without assistance from splicing activators. This 3' splice acceptor site is therefore not used in males. Females, however, produce the splicing activator Transformer (Tra). The SR protein Tra2 is produced in both sexes and binds to an ESE in exon 4; if Tra is present, it binds to Tra2 and, along with another SR protein, forms a complex that assists U2AF proteins in binding to the weak polypyrimidine tract. U2 is recruited to the associated branch point, and this leads to inclusion of exon 4 in the mRNA[1][2].

Notes

  1. a b Lynch KW, Maniatis T (August 1996). "Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer". Genes Dev. 10 (16): 2089–101. PMID 8769651.
  2. Graveley BR, Hertel KJ, Maniatis T (June 2001). "The role of U2AF35 and U2AF65 in enhancer-dependent splicing". RNA 7 (6): 806–18. PMID 11421359. PMC: 1370132.
Source Own work
Author Agathman

Licensing

[edit]
I, the copyright holder of this work, hereby publish it under the following license:
w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current20:23, 30 April 2009Thumbnail for version as of 20:23, 30 April 2009876 × 499 (83 KB)Agathman (talk | contribs){{Information |Description={{en|1=Alternative splicing of ''Drosophila dsx'' gene. Pre-mRNAs from the ''D. melanogaster'' gene ''dsx'' contain 6 exons. In males, exons 1,2,3,5,and 6 are joined to form the mRNA, which encodes a transcriptional regulatory

There are no pages that use this file.

File usage on other wikis

The following other wikis use this file:

Metadata