File:Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS).jpg
Diagram_showing_a_pancreatic_islet_and_four_stages_of_T1D_disease_driven_by_heparanase_and_loss_of_intra-islet_glycosaminoglycan_heparan_sulfate_(HS).jpg (640 × 486 pixels, file size: 82 KB, MIME type: image/jpeg)
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[edit]DescriptionDiagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS).jpg |
English: Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet HS. HS (intense blue color) is shown in normal beta cells and in intact peri-islet BM. In Stage 1 of the disease process, non-destructive insulitis mononuclear cells produce heparanase (red dots). Onset of destructive insulitis occurs when heparanase becomes catalytically active and degrades HS in the islet BM (Stage 2). Damage to the islet BM barrier allows activated autoreactive T cells to enter the islet cell mass where the local production of heparanase leads to degradation of intracellular HS in islet beta cells (paling blue color; Stage 3). Progression of HS depletion throughout the islet beta cell population results in increased beta cell death (palest blue color in “shriveled” beta cells; Stage 4), loss of insulin production and ultimately the development of T1D. MNC, mononuclear cell; BM, basement membrane; Hpse, heparanase. |
Date | |
Source | https://doi.org/10.3389/fimmu.2013.00471 |
Author | Charmaine Simeonovic, Andrew Ziolkowski, Zuopeng Wu, Fui Jiun Choong, Craig Freeman, Christopher R Parish |
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current | 18:13, 30 May 2021 | ![]() | 640 × 486 (82 KB) | PossiblyAKiwi (talk | contribs) | Uploaded a work by Charmaine Simeonovic, Andrew Ziolkowski, Zuopeng Wu, Fui Jiun Choong, Craig Freeman, Christopher R Parish from https://doi.org/10.3389/fimmu.2013.00471 with UploadWizard |
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Software used | Adobe Photoshop CS5 Windows |
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Date and time of digitizing | 22:43, 26 November 2013 |
File change date and time | 20:06, 21 December 2013 |
Date metadata was last modified | 20:06, 21 December 2013 |
Unique ID of original document | uuid:1E893E1E2258E311AB79D39C35211B28 |
Copyright status | Copyright status not set |