File:Diagnosis of diffuse glioma.png
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this preview: 744 × 600 pixels. Other resolutions: 298 × 240 pixels | 595 × 480 pixels | 953 × 768 pixels | 1,270 × 1,024 pixels | 2,153 × 1,736 pixels.
Original file (2,153 × 1,736 pixels, file size: 205 KB, MIME type: image/png)
File information
Structured data
Captions
Summary
[edit]DescriptionDiagnosis of diffuse glioma.png |
English: Diagnostic algorithm for the integrated classification of the major diffuse gliomas in adults. Tissue specimens obtained through biopsy sampling in patients with diffuse gliomas are routinely assessed by immunohistochemistry for the presence of R132H-mutant IDH1 and loss of nuclear ATRX. In patients aged >55 years with a histologically typical glioblastoma, without a pre-existing lower grade glioma, with a non-midline tumor location and with retained nuclear ATRX expression, immunohistochemical negativity for IDH1 R132H suffices for the classification as IDH-wild-type glioblastoma. In all other instances of diffuse gliomas, a lack of IDH1 R132H immunopositivity should be followed by IDH1 and IDH2 DNA sequencing to detect or exclude the presence of non-canonical mutations. IDH-wild-type diffuse astrocytic gliomas without microvascular proliferation or necrosis should be tested for EGFR amplification, TERT promoter mutation and a +7/–10 cytogenetic signature as molecular characteristics of IDH-wild-type glioblastomas. In addition, the presence of histone H3.3 G34R/V mutations should be assessed by immunohistochemistry or DNA sequencing to identify H3.3 G34-mutant diffuse hemispheric gliomas, in particular in young patients with IDH-wild-type gliomas (such as those <50 years of age with nuclear ATRX loss in tumour cells). Diffuse gliomas of the thalamus, brainstem or spinal cord should be evaluated for histone H3 K27M mutations and loss of nuclear K27-trimethylated histone H3 (H3K27me3) to identify H3 K27M-mutant diffuse midline gliomas. The presence and absence of the diagnostically most relevant molecular alterations for each tumor type are highlighted with red and green boxes. MVP, microvascular proliferation. |
Date | |
Source |
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G (2021). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.". Nat Rev Clin Oncol 18 (3): 170-186. DOI:10.1038/s41571-020-00447-z. PMID 33293629. PMC: 7904519. "This article is licensed under a Creative Commons Attribution 4.0 International License" |
Author |
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G et al Few colored boxes added by Mikael Häggström |
Licensing
[edit]This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 14:58, 9 April 2024 | 2,153 × 1,736 (205 KB) | Mikael Häggström (talk | contribs) | Few colored boxes added | |
14:51, 15 March 2024 | 2,153 × 1,736 (286 KB) | Mikael Häggström (talk | contribs) | Uploaded a work by Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G et al from {{cite journal| author=Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G | display-authors=etal| title=EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. | journal=Nat Rev Clin Oncol | year= 2021 | volume= 18 | issue= 3 | pages= 170-186 | pmid=33293629 | doi=10.1038/s41571-020-00447-z | pmc=7904519 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/eli... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Unique ID of original document | xmp.did:9c148358-6ca7-4ec3-a24e-caedc2cb1d02 |
---|---|
Software used | GIMP 2.10 |
Horizontal resolution | 37.8 dpc |
Vertical resolution | 37.8 dpc |
File change date and time | 14:37, 15 March 2024 |
Hidden category: