File:Cutaneous minocycline hyperpigmentation (49676469778).jpg

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Minocycline is a tetracycline derivative antibiotic commonly prescribed for acne, rosacea, and other inflammatory skin disorders. Minocycline turns black when oxidized, leading to discoloration of the skin and nails. Pigmentation may also involve the bulbar conjunctiva, oral mucosa, teeth, bones, and thyroid gland. Pigmentation has been reported after long-term minocycline therapy with at least 100 mg/day.

Cutaneous minocycline hyperpigmentation is divided into 3 types; see last image. Type I is thought to be related to an iron chelate of minocycline Type II is probably secondary to a drug metabolite protein complex chelated with iron and calcium In Type III pigmentation is probably related to a photo drug induced dermatitis and melanin drop down from the basal layer

Images and text for 2nd paragraph contributed by Dr. Silvija Gottesman - @SGottesmanMD
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Source Cutaneous minocycline hyperpigmentation
Author Atlas of Medical Foreign Bodies

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This image was originally posted to Flickr by Y. Rosen, MD at https://flickr.com/photos/158161000@N04/49676469778. It was reviewed on 15 February 2021 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-sa-2.0.

15 February 2021

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current19:42, 15 February 2021Thumbnail for version as of 19:42, 15 February 20211,280 × 720 (338 KB)Netha Hussain (talk | contribs)Transferred from Flickr via #flickr2commons

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