File:Cumulative maximum Exposure-Activity Ratios (∑EAR) and human-health benchmark cumulative toxicity quotient (ΣTQ) for 15 PFAS in U.S. tapwater.jpg

English: "Solid red and yellow lines indicate concentrations shown to modulate effects in vitro and effects-screening-level thresholds" "Left. Cumulative maximum Exposure-Activity Ratios (∑EAR) across all assays for 9 individual per- and polyfluoroalkyl substances (PFAS) in ToxCast and detected in tapwater collected from public-supply and private-wells. Solid red and yellow lines indicate concentrations shown to modulate effects in vitro and effects-screening-level thresholds (EAR = 1 and EAR = 0.001), respectively. Right. Human-health benchmark cumulative toxicity quotient (ΣTQ) for 15 PFAS listed in Table S5 and tapwater from public-supply and private-wells. Solid red and yellow lines indicate benchmark equivalent concentrations and effects-screening-level threshold of concern (TQ = 0.1), respectively. Boxes, centerlines, and whiskers indicate interquartile range, median, and 5th and 95th percentiles, respectively. Numbers above each boxplot pair indicate the permuted probability that the centroids and dispersions are the same (PERMANOVA; 9999 permutations). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"