File:Cortical cells form dense interconnected networks when trained to play Pong.jpg
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Summary
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| Description |
English: "(A and B) Cortical cells from E15 mouse brains and differentiated from hiPSCs, respectively. DAPI in blue stains all cells, NeuN in green shows neurons, beta III tubulin (BIII) marks axons, while MAP2 marks dendrites. Scale bar = 50μm.
(C) GFAP shows supporting astrocytes, critical for long-term functioning; TBR1 marks cortex-specific cells. No Ki67, a marker of dividing cells, was observed with these cultures. Scale bar = 50μm. (D) Gene expression studies over 28 days demonstrated increased expression of the glutamatergic neural marker, vesicular glutamate transporter 1 (vGLUT1). (E–G) Neurons differentiated from hiPSCs using the DSI protocol, maintained on MEA for >3 months. White arrows show regions of shrinkage within the cultures, red arrows show bundles of axons, and blue arrows show single neurite extensions. Note the dense coverage over the HD-MEA and overlapping connections extended from neuronal soma present in all cultures across multiple electrodes. Scale bars: E = 200μm, F = 100μm, G = 50μm (H) Has false coloring to highlight the HD-MEA electrodes beneath the cells. Scale bar = 20μm." |
| Date | |
| Source | https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 |
| Author |
Authors of the study: Brett J. Kagan Andy C. Kitchen Nhi T. Tran Forough Habibollahi Moein Khajehnejad Bradyn J. Parker Anjali Bhat Ben Rollo Adeel Razi Karl J. Friston |
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| current | 20:38, 3 April 2023 | | 3,358 × 4,012 (3.63 MB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Brett J. Kagan Andy C. Kitchen Nhi T. Tran Forough Habibollahi Moein Khajehnejad Bradyn J. Parker Anjali Bhat Ben Rollo Adeel Razi Karl J. Friston from https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 with UploadWizard |
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