File:Contribution of EMT to cancer progression.jpg

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Figure 5. Contribution of EMT to cancer progression

Progression from normal epithelium to invasive carcinoma goes through several stages. The invasive carcinoma stage involves epithelial cells losing their polarity and detaching from the basement membrane. The composition of the basement membrane also changes, altering cell-ECM interactions and signaling networks. The next step involves EMT and an angiogenic switch, facilitating the malignant phase of tumor growth. Progression from this stage to metastatic cancer also involves EMTs, enabling cancer cells to enter the circulation and exit the blood stream at a remote site, where they may form micro- and macro-metastases, which may involve METs and thus a reversion to an epithelial phenotype.
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Source https://www.jci.org/articles/view/39104 The basics of epithelial-mesenchymal transition J Clin Invest. 2009;119(6):1420-1428. https://doi.org/10.1172/JCI39104.
Author Raghu Kalluri, Robert A. Weinberg
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Open access https://www.jci.org/kiosks/terms The JCI is a Gold Open Access journal in which all content is freely available wthout charge to the user or their institution. Effective with the January 4, 2022, issue, all content is published with a Creative Commons Attribution License (CC BY 4.0).

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current00:35, 20 May 2024Thumbnail for version as of 00:35, 20 May 20241,704 × 344 (425 KB)Rasbak (talk | contribs){{Information |description=Figure 5. Contribution of EMT to cancer progression<br> Progression from normal epithelium to invasive carcinoma goes through several stages. The invasive carcinoma stage involves epithelial cells losing their polarity and detaching from the basement membrane. The composition of the basement membrane also changes, altering cell-ECM interactions and signaling networks. The next step involves EMT and an angiogenic switch, facilitating the malignant phase of tumor grow...

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