File:Comparison across several species of establishment of hypoblast signalling centre.png
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Fig 10. Comparison across several species of establishment of hypoblast signalling centre. In mice, negative signals (black arrows; BMP) from the trophoblast (in blue) are believed to inhibit the establishment of a distal hypoblast signalling centre until the epiblast (in red) has proliferated sufficiently to remove some of the visceral hypoblast (in yellow; in mice termed the visceral primitive endoderm, or VE) from this influence allowing the DVE (orange) to form at distances greater than 60 μm. A conceptual flattening out of the mouse egg cylinder is shown. In rabbits, CER1, marking the initially centrally and symmetrically located DVE equivalent, termed the AMC, again forms at a distance from the trophoblast margin. In cattle, persistence of the polar trophoblast (Rauber’s layer) and a more lens-like transverse shape of the epiblast infer that the VH remains under the influence of putative inhibitory signals, precluding a DVE-like precursor population of the AVH |
| Date | |
| Source | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129787 van Leeuwen J, Berg DK, Pfeffer PL (2015) Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos. PLoS ONE 10(6): e0129787. https://doi.org/10.1371/journal.pone.0129787 |
| Author | van Leeuwen J, Berg DK, Pfeffer PL |
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© 2015 van Leeuwen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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| current | 14:18, 28 August 2024 | | 1,624 × 1,234 (90 KB) | Rasbak (talk | contribs) | {{Information |description=Fig 10. Comparison across several species of establishment of hypoblast signalling centre. In mice, negative signals (black arrows; BMP) from the trophoblast (in blue) are believed to inhibit the establishment of a distal hypoblast signalling centre until the epiblast (in red) has proliferated sufficiently to remove some of the visceral hypoblast (in yellow; in mice termed the visceral primitive endoderm, or VE) from this influence allowing the DVE (orange) to form... |
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