File:Classic leptin–melanocortin model.jpg
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[edit]DescriptionClassic leptin–melanocortin model.jpg |
English: " Leptin is secreted predominantly by the adipose tissue and reaches the brain parenchyma through the bloodstream. The arcuate nucleus of the hypothalamus (ARC) hosts AGRP/NPY and POMC neurons, two distinct antagonistic neuronal populations that have been shown to express Lepr-b (Cheung et al., 1997; Mercer, Hoggard, Williams, Lawrence, Hannah, Morgan, et al., 1996; Mercer, Hoggard, Williams, Lawrence, Hannah, & Trayhurn, 1996). This model proposed that leptin acts directly on those neurons to induce opposite effects. Thus, high leptin levels, signaling a positive energy state, would activate POMC neurons and inhibit AGRP/NPY neurons to promote satiety. On the other hand, low leptin levels would activate AGRP/NPY neurons and inhibit POMC neurons, promoting food intake. Once activated, the first-order AGRP/NPY and POMC neurons would affect second-order neurons, located outside of the ARC, by releasing NPY, AGRP, or POMC-derived α-MSH. Via their action on second-order neurons, these peptides would then induce broad effects on energy homeostasis (Schwartz et al., 2000). AGRP, agouti-related peptide; LEPR, leptin receptor; NPY, neuropeptide Y; POMC, pro-opiomelanocortin; α-MSH, α-melanocyte-stimulating hormone." |
Date | 17 January 2023 |
Source | https://onlinelibrary.wiley.com/doi/10.1111/jnc.15765 |
Author | Olivier Lavoie, Natalie Jane Michael, Alexandre Caron |
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current | 01:25, 6 December 2023 | 2,128 × 3,029 (388 KB) | Buidhe (talk | contribs) | Uploaded a work by Olivier Lavoie, Natalie Jane Michael, Alexandre Caron from https://onlinelibrary.wiley.com/doi/10.1111/jnc.15765 with UploadWizard |
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