File:Chemical structures of TET-oxidized products.jpg
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| Description | Figure 2. Chemical structures of TET-oxidized products. The DNA base cytosine can be methylated as epigenetic regulation at the DNA level by DNMTs. DNA methylation affects transcription and governs genomic stability during development as well as cancer progression. The methylated product (5-methylcytosine, 5mC) can be reversed actively by a set of enzymes, TET proteins and TDG back to cytosine. The intermediate products include: 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). The amount of 5hmC serves as a marker to indicate the status of DNA demethylation. Loss of 5hmC is often seen in cancers, particularly in myeloid and leukemia. TET: the Ten-eleven translocation family protein; DNMT: DNA methyltransferase; TDG: thymine-DNA glycosylase. |
| Date | |
| Source | https://www.researchgate.net/publication/293042602_Hypoxia_Epithelial-Mesenchymal_Transition_and_TET-Mediated_Epigenetic_Changes Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes Journal of Clinical Medicine February 20165(2):24 DOI:10.3390/jcm5020024 |
| Author | Shih-Han Kao, Kou-Juey Wu and Wen-Hwa Lee |
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© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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| current | 19:02, 20 May 2024 | | 839 × 590 (129 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 2. Chemical structures of TET-oxidized products. The DNA base cytosine can be methylated as epigenetic regulation at the DNA level by DNMTs. DNA methylation affects transcription and governs genomic stability during development as well as cancer progression. The methylated product (5-methylcytosine, 5mC) can be reversed actively by a set of enzymes, TET proteins and TDG back to cytosine. The intermediate products include: 5-hydroxymethylcytosine (5hmC), 5-for... |
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