File:Cellular mechanisms and molecular pathways in Müllerian duct development.jpg
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| Description | Figure 2. Cellular mechanisms and molecular pathways in Müllerian duct development. Several cellular mechanisms chronologically succeed during chicken Müllerian duct development (A). In (B), early stages in Müllerian duct development are governed by the BMP pathway regulating Pax2, activating the FGF/RAS/ERK pathway and promoting Lim1 expression and apical constriction control. Dach1/2 and Pax2 also regulate Lim1. Later, development proceeds through rostral-caudal elongation depending on Wolffian paracrine signals, such as Lim1-regulated Wnt9b, which activates the Wnt Canonical pathway. Besides, the PI3k/Akt pathway, coelomic epithelium signaling and Wnt4, Gata3, Gpr56, and Dmrt1 regulate elongation. Genes/pathways in bold are expressed/intrinsic to Müllerian epithelial cells, genes in light are expressed by mesonephric mesenchymal cells and genes in gray are expressed by Wolffian epithelial cells. |
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| Source | https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.605301/full Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct. Front. Cell Dev. Biol. 9:605301. doi: 10.3389/fcell.2021.605301 |
| Author | Santana Gonzalez L, Rota IA, Artibani M, Morotti M, Hu Z, Wietek N, Alsaadi A, Albukhari A, Sauka-Spengler T and Ahmed AA |
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© 2021 Santana Gonzalez, Rota, Artibani, Morotti, Hu, Wietek, Alsaadi, Albukhari, Sauka-Spengler and Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 21:02, 7 July 2024 | | 2,469 × 2,896 (573 KB) | Rasbak (talk | contribs) | {{Information |description= Figure 2. Cellular mechanisms and molecular pathways in Müllerian duct development. Several cellular mechanisms chronologically succeed during chicken Müllerian duct development (A). In (B), early stages in Müllerian duct development are governed by the BMP pathway regulating Pax2, activating the FGF/RAS/ERK pathway and promoting Lim1 expression and apical constriction control. Dach1/2 and Pax2 also regulate Lim1. Later, development proceeds through rostral-caudal... |
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