File:Cell–cell interactions and external signals regulating collective cell migration of cephalic NC cells.jpg
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| Description | Fig. 7. Cell–cell interactions and external signals regulating collective cell migration of cephalic NC cells. (A) Xenopus cephalic NC cells start migrating as a cell sheet. Cells located at the border of the population exhibit a clear cell polarity with cell protrusions oriented towards the outside. On the contrary, cells inside the population that are completely surrounded by other NC cells show no obvious polarity and display only cryptic protrusions. As migration proceeds the population becomes more mesenchymal and migration turns into a cell streaming. Cell–cell contacts in groups or between single cells trigger Contact-Inhibition of Locomotion (CIL, red inhibitory arrows) which leads to the collapse of cell protrusions. CIL, through its effect on cell polarity, is essential for coordinated migration and sensing of external cues. Cells that lose contacts with other cells have poor chemotactic response (tortuous path) but are actively attracted back towards other NC cells by co-attraction (blue arrows). Modified after Theveneau et al. (2010) and Carmona-Fontaine et al. (2011). See main text for details. (B) Chick cephalic NC cells undergo cell streaming and chain migration. Collisions between cells lead to the collapse of cell protrusions reminiscent of CIL (red inhibitory arrows) and a gathering behavior reminiscent of CoA (blue arrows). Modified after Teddy and Kulesa (2004). In both Xenopus and chick isolated cells migrate less efficiently than cells in groups or chains (shown as tumultuous paths). NC cells at the border of a stream may encounter NC cells from an adjacent stream (gray cells) but differential expressions of ephrin/Eph molecules prevent mixing. In addition, inhibitors (ephrins/Eph, class3-semaphorins) present in the surrounding tissues (shades of pink) induce the collapse of cell protrusions and restrict NC migration to specific routes. Finally, chemotactic and chemokinetic factors promoting motility and targeting NC cells to specific locations are shown as shades of green. |
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https://www.sciencedirect.com/science/article/pii/S0012160611014692?via%3Dihub Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration, Developmental Biology, Volume 366, Issue 1, 2012, Pages 34-54, ISSN 0012-1606, https://doi.org/10.1016/j.ydbio.2011.12.041. (https://www.sciencedirect.com/science/article/pii/S0012160611014692) |
| Author | Eric Theveneau, Roberto Mayor, |
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| current | 07:06, 3 June 2024 | | 1,654 × 1,158 (387 KB) | Rasbak (talk | contribs) | {{Information |description=Fig. 7. Cell–cell interactions and external signals regulating collective cell migration of cephalic NC cells. (A) Xenopus cephalic NC cells start migrating as a cell sheet. Cells located at the border of the population exhibit a clear cell polarity with cell protrusions oriented towards the outside. On the contrary, cells inside the population that are completely surrounded by other NC cells show no obvious polarity and display only cryptic protrusions. As migratio... |
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