File:CIN 3 With Gland Involvement (3614070242).jpg

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This lady had a negative Pap in 2007. The most recent Pap (2009) is a SurePath, which was called ASC-US (atypical squamous cells of undetermined significance) by a highly experienced, subspecialty-boarded cytopathologist. On review, there are a few naked hyperchromatic nuclei which may correlate with the lesion, but otherwise the Pap is pretty bland.

Clinicians seem to like SurePath better than ThinPrep, because with SurePath you just break off the collector in the holding medium, while you have to do some swishing and swirling to inoculate the ThinPrep medium. I have been certified to read SurePath for only 10 months, so I am reserving final judgment, but from what I have seen so far, I think SurePath is considerably more treacherous than ThinPrep on the interpretive side, and my provisional recommendation to clinicians and patients is to insist on ThinPrep.

By the way, I don't have any material interest in either product. However, I do have a material interest in getting the right diagnosis, which is why I'm recommending ThinPrep.

Pathological and histological images courtesy of Ed Uthman at flickr.
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CIN 3 With Gland Involvement

Author Ed Uthman from Houston, TX, USA

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This image, originally posted to Flickr, was reviewed on 11 December 2013 by the administrator or reviewer File Upload Bot (Magnus Manske), who confirmed that it was available on Flickr under the stated license on that date.

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