File:Biomedicines-10-02464-g001-550.webp
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Biomedicines-10-02464-g001-550.webp (550 × 294 pixels, file size: 12 KB, MIME type: image/webp)
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Obeticholic Acid
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[edit]DescriptionBiomedicines-10-02464-g001-550.webp |
English: Figure 1. Molecular mechanism of hepatic OCA pharmacodynamics. OCA activates FXR, thereby triggering cellular pathways leading to a reduction in the synthesis and hepatic uptake of BAs, and an increase in their efflux from the liver. Furthermore, OCA acts on LSEC and KC, exerting anti-inflammatory and antifibrotic effects by reducing the production of proinflammatory cytokines and HSC activation, respectively. Abbreviations: farnesoid X receptor (FXR), retinoid X receptor (RXR), bile acid (BA), Kupffer cell (KC), liver sinusoidal endothelial cell (LSEC), hepatic stellate cell (HSC), small heterodimer partner (SHP), liver receptor homolog 1 (LRH-1), fibroblast growth factor-19 (FGF-19), sodium taurocholate co-transporting polypeptide (NTCP), bile salt export pump (BSEP), multidrug resistance protein-3 (MDR3), organic solute transporters (OST), transforming growth-factor β (TGFβ), connective tissue growth factor (CTGF), platelet-derived growth factor β-receptor (PDGFR-β), monocyte chemo-attractant protein-1 (MCP1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), inhibitor of kB (IκB). |
Date | |
Source | https://www.mdpi.com/2227-9059/10/10/2464 |
Author | Floreani, A.; Gabbia, D.; De Martin, S. |
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current | 17:46, 1 March 2024 | ![]() | 550 × 294 (12 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Floreani, A.; Gabbia, D.; De Martin, S. from https://www.mdpi.com/2227-9059/10/10/2464 with UploadWizard |
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