File:Bar plot of average number of de novo mutations by chromosome.jpg

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English: Bar plot of average number of de novo mutations by chromosome. The average number of de novo point mutations (DNMs) in each autosome are largely correlated with the chromosome sizes. The error bars represent the s.e. (standard error) of the mean DNMs for each chromosome. Numbers of DNMs in chromosomes 17, 19, 20, 21 and 22 are not significant for either father’s or mother’s age (P>0.05). Numbers of DNMs in chromosomes 1–4, 6, 8–15 and 18 are significantly correlated with father’s age only. Numbers of DNMs in chromosomes 5, 7, 16 are significantly correlated with both parents’ ages.


Whole-genome deep sequencing data from 693 mother–father–newborn trios, the ages of the fathers at conception ranged from 17 to 63 years, with a mean of 33.4 years. Twenty-four (3.5%) of the fathers were older than 45 years. The ages of the mothers ranged from 17 to 43 years with a mean of 31.2 years. The gestational age of the newborns ranged from 23 to 42 weeks with a mean of 37.2 weeks.
Date Published 19 January 2016
Source Wong, W. S. W. et al. New observations on maternal age effect on germline de novo mutations. Nat. Commun. 7:10486 doi: 10.1038/ncomms10486 (2016). http://www.nature.com/ncomms/2016/160119/ncomms10486/full/ncomms10486.html
Author Wendy S. W. Wong, Benjamin D. Solomon, Dale L. Bodian, Prachi Kothiyal, Greg Eley, Kathi C. Huddleston, Robin Baker, Dzung C. Thach, Ramaswamy K. Iyer, Joseph G. Vockley & John E. Niederhuber
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Parents’ age distribution with number of de novo mutations in their offsprings
De novo mutations by age of father and mother
Distribution of the ratios between number of DNMs of maternal origin and paternal origin

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