File:Antibiotic clovibactin from an uncultured bacterium binds to an immutable target (graphical abstract).jpg
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From "An antibiotic from an uncultured bacterium binds to an immutable target"
Summary
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| Description |
English: "Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant Gram-positive bacterial pathogens without detectable resistance. Using biochemical assays, solid-state nuclear magnetic resonance, and atomic force microscopy, we dissect its mode of action. Clovibactin blocks cell wall synthesis by targeting pyrophosphate of multiple essential peptidoglycan precursors (C55PP, lipid II, and lipid IIIWTA). Clovibactin uses an unusual hydrophobic interface to tightly wrap around pyrophosphate but bypasses the variable structural elements of precursors, accounting for the lack of resistance. Selective and efficient target binding is achieved by the sequestration of precursors into supramolecular fibrils that only form on bacterial membranes that contain lipid-anchored pyrophosphate groups. This potent antibiotic holds the promise of enabling the design of improved therapeutics that kill bacterial pathogens without resistance development." |
| Date | |
| Source | https://www.cell.com/cell/fulltext/S0092-8674(23)00853-X |
| Author |
Authors of the study: Rhythm Shukla Aaron J. Peoples Kevin C. Ludwig Sourav Maity Maik G.N. Derks Stefania De Benedetti Annika M. Krueger Bram J.A. Vermeulen Theresa Harbig Francesca Lavore Raj Kumar Rodrigo V. Honorato Fabian Grein Kay Nieselt Yangping Liu Alexandre M.J.J. Bonvin Marc Baldus Ulrich Kubitscheck Eefjan Breukink Catherine Achorn Anthony Nitti Christopher J. Schwalen Amy L. Spoering Losee Lucy Ling Dallas Hughes Moreno Lelli Wouter H. Roos Kim Lewis Tanja Schneider Markus Weingarth. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:34, 15 October 2023 | | 996 × 996 (245 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Rhythm Shukla Aaron J. Peoples Kevin C. Ludwig Sourav Maity Maik G.N. Derks Stefania De Benedetti Annika M. Krueger Bram J.A. Vermeulen Theresa Harbig Francesca Lavore Raj Kumar Rodrigo V. Honorato Fabian Grein Kay Nieselt Yangping Liu Alexandre M.J.J. Bonvin Marc Baldus Ulrich Kubitscheck Eefjan Breukink Catherine Achorn Anthony Nitti Christopher J. Schwalen... |
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