File:Anatomical substrates for vertical and horizontal saccades.png

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English: Anatomical substrates for vertical and horizontal saccades. This picture illustrates the brainstem excitatory burst neurons and neural integrators for horizontal and vertical saccades, as well as examples of disorders affecting these structures. For horizontal saccades, excitatory burst neurons are located in the paramedian pontine reticular formation (PPRF) in the pons. The medial vestibular nucleus/nucleus prepositus hypoglossi (MVN/NPH) in the medulla are the horizontal neural integrators. For vertical saccades, excitatory burst neurons are predominantly located in the rostral interstitial nucleus of the medial longitudinal fasciculus (RIMLF), and the interstitial nucleus of Cajal (INC) is the vertical neural integrator. Both of these are in the midbrain. The nucleus raphe interpositus (RIP) in the pons houses the omnipause neurons. *Lesion may not be direct lesion of the MVN/NPH, but may be lesion of the cerebellar feedback circuitry to these structures. Abbreviations: PSP, progressive supranuclear palsy; NPC, Niemann-Pick type C; SCA2, spinocerebellar ataxia type 2; OMAS, opsoclonus-myoclonus ataxia syndrome; MSA, multiple system atrophy; RIMLF, rostral interstitial nucleus of the medial longitudial fasciculus; INC, interstitial nucleus of Cajal; PPRF, paramedian pontine reticular formation; RIP, nucleus raphe interpositus; MVN/NPH, medial vestibular nucleus/nucleus prepositus hypoglossi
Date Published online 2015 Oct 15
Source Termsarasab P, Thammongkolchai T, Rucker JC, Frucht SJ. The diagnostic value of saccades in movement disorder patients: a practical guide and review. J Clin Mov Disord. 2015;2:14. Published 2015 Oct 15. https://doi.org/10.1186/s40734-015-0025-4
Author Pichet Termsarasab, Thananan Thammongkolchai, Janet C. Rucker, and Steven J. Frucht

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current13:39, 8 June 2019Thumbnail for version as of 13:39, 8 June 20191,183 × 692 (596 KB)Was a bee (talk | contribs){{Information |Description={{en|1=Anatomical substrates for vertical and horizontal saccades. This picture illustrates the brainstem excitatory burst neurons and neural integrators for horizontal and vertical saccades, as well as examples of disorders affecting these structures. For horizontal saccades, excitatory burst neurons are located in the paramedian pontine reticular formation (PPRF) in the pons. The medial vestibular nucleus/nucleus prepositus hypoglossi (MVN/NPH) in the medulla are...

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