File:Albendazole metabolism.svg
Original file (SVG file, nominally 622 × 179 pixels, file size: 65 KB)
Captions
Summary
[edit]DescriptionAlbendazole metabolism.svg |
English: Albendazole is metabolized into R(+)-albendazole sulfoxide and S(-)-albendazole sulfoxide. Both are metabolized to albendazole sulfone. |
Date | |
Source | Own work |
Author | Prof. Squirrel |
Other versions | |
SVG development InfoField | This structural formula was created with Adobe Illustrator. |
References:
- Capece, Bettencourt P. S.; Virkel, Guillermo L.; Lanusse, Carlos E. (2009). "Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications". The Veterinary Journal 181 (3): 241-250. DOI:10.1016/j.tvjl.2008.11.010. ISSN 1090-0233.
- Rawden, Helen C.; Kokwaro, Gilbert O.; Ward, Stephen A.; Edwards, Geoffrey (2004). "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes". British Journal of Clinical Pharmacology 49 (4): 313-322. DOI:10.1046/j.1365-2125.2000.00170.x. ISSN 1365-2125.
Made using the chemfig
package in LaTex:
}
\renewcommand{\familydefault}{\sfdefault}
\begin{document} \hspace{-1.5in} \schemestart % ALBENDAZOLE @c1 \chemname{
\chemfig{ -[:30] -[:-30] -[:30]S -[:-30] *6( = %bottom - = *5(-N = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] ) -\chemabove{N}{H} - - ) - %top = - ) }
}{albendazole} \arrow(.mid east--.mid west){<->[FMO][]}[30,2] % alb -> + alb sulfoxide \setlewis{}{}{magenta} %ALBENDAZOLE SULFOXIDE (+) \chemname{
\chemfig{ -[:30] -[:-30] -[:30]S ( <[:120,1.25,,,,magenta]\color{magenta}{O} ) ( <:[:50,1.25,,,,magenta]\color{white}{\Lewis{1:,.}} ) -[:-30] *6( = %bottom - = *5(-N = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] ) -\chemabove{N}{H} - - ) - %top = - ) }
}{R(+)-albendazole sulfoxide} \arrow(@c1.mid east--.mid west){<->[][CYP]}[-30,2] % alb -> - alb sulfoxide \arrow(@c2.east--@c4.west){->[\sf{CYP}]}[30,2] \setlewis{}{}{magenta} %ALBENDAZOLE SULFOXIDE (-) \chemname {
\chemfig{ -[:30] -[:-30] -[:30]S ( <[:120,1.25,,,,magenta]\color{white}{\Lewis{3:,.}} ) ( <:[:50,1.25,,,,magenta]\color{magenta}{O} ) -[:-30] *6( = %bottom - = *5(-N = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] ) -\chemabove{N}{H} - - ) - %top = - ) }
}{S(-)-albendazole sulfoxide} \arrow(.east--.west){->[][CYP]}[30,2] %ALBENDAZOLE SULFONE \chemname {
\chemfig{ -[:30] -[:-30] -[:30]S ( =[:60,,,,,magenta]\color{magenta}{O} )( =[:120,,,,,magenta]\color{magenta}{O} ) -[:-30] *6( = %bottom - = *5(-N = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] ) -\chemabove{N}{H} - - ) - %top = - ) }
}{albendazole sulfone} \schemestop \end{document} }}
Licensing
[edit]Public domainPublic domainfalsefalse |
This image of a simple structural formula is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship. |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 04:16, 8 August 2017 | 622 × 179 (65 KB) | Prof. Squirrel (talk | contribs) | User created page with UploadWizard |
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Width | 622px |
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Height | 179px |