File:Acyl Transfer Strategies as Transient Activations for Enantioselective Synthesis (MédiHAL 2279710).jpg

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Acyl_Transfer_Strategies_as_Transient_Activations_for_Enantioselective_Synthesis_(MédiHAL_2279710).jpg (455 × 102 pixels, file size: 10 KB, MIME type: image/jpeg)

Captions

Captions

In order to circumvent reactivity or selectivity issues associated with the addition of enolates to electrophiles, chemists have devised innovative methods involving transient activating groups.

Summary

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Description
English: In order to circumvent reactivity or selectivity issues associated with the addition of enolates to electrophiles, chemists have devised innovative methods involving transient activating groups. One of these powerful methods consists of the use of activated ketones, such as -nitroketones, -dicarbonyl compounds or -ketosulfones, with electrophiles possessing a latent hydroxy or amine function. In the presence of a suitable catalyst, an enantioselective addition to the electrophile is facilitated triggering a subsequent Claisen-type fragmentation resulting in an acyl transfer. This subsequent step unveils the desired mono-activated function while directly transferring the ketone, forming in situ on the other side an ester or an amide.
Date Taken on 15 April 2019
Source Acyl Transfer Strategies as Transient Activations for Enantioselective Synthesis
Author

Jean Rodriguez, Adrien Quintard

Adrien Quintard   wikidata:Q81717626
 
Description researcher
Authority file
creator QS:P170,Q81717626
institution QS:P195,Q30295259
institution QS:P195,Q2302586
institution QS:P195,Q3152386
institution QS:P195,Q280413
Keywords
InfoField
Enantioselective synthesis; Organocatalysis; Fragmentation

Licensing

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Public domain
This work is in the public domain in France for one of the following reasons:
  • Its author (or the last of its authors in the case of a collaboration work) died more than 70 years ago (CPI art. L123-1) and did not benefit from any copyright extension (CPI art. L123-8, L123-9 and L123-10)[1];
  • It is an anonymous or pseudonymous work (the identity of the author has never been disclosed) or a collective work[2] and more than 70 years have passed since its publication (CPI art. L123-3);
  • It is the recording of an audiovisual or musical work already in the public domain, and more than 50 years have passed since the performance or the recording (CPI art. L211-4).
Please note that moral rights still apply when the work is in the public domain. They encompass, among others, the right to the respect of the author's name, quality and work (CPI art. L121-1). Attribution therefore remains mandatory.
  1. ↑ Copyright extensions must be considered only in the case of musical works and of authors Mort pour la France (died during conflict, in the service of France). In other cases, they are included in the 70 years post mortem auctoris length (see this statement of the Cour de Cassation).
  2. ↑ The collective work status is quite restrictive, please make sure that it is actually established.

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