File:Aberrant-Expression-of-Interleukin-1β-and-Inflammasome-Activation-in-Human-Malignant-Gliomas-pone.0103432.g002.jpg

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Aberrant-Expression-of-Interleukin-1β-and-Inflammasome-Activation-in-Human-Malignant-Gliomas-pone.0103432.g002.jpg ‎(688 × 568 pixels, file size: 70 KB, MIME type: image/jpeg)

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English: Three patient-derived glioma cell lines (one low grade astrocytoma and two GBM cells) were tested for IL-1 protein production spontaneously (Ctr) and following IL-1/IFNγ stimulation. ELISA was performed with cell lysates (intracellular = i.c.) and culture supernatants (secreted = s). (A) IL-1 protein production was seen in GBM cells only. In one of them (GBM2), IL-1 production occurred spontaneously (Ctr) and was potentiated by IL-1 (± IFNγ). A portion of IL-1 was secreted. (B) Dose-dependent induction of IL-1: production of IL-1β was examined in GBM2 cells after stimulation with different concentrations (0.1 pg/ml to 100 ng/ml) of IL-1α. (C) IL-1β immunostain of unstimulated GBM2 cells reveals scattered positive cells, while preimmune IgG (negative control) showed no positive cells. Data shown are mean ± SD (n = 3), ***p<0.001, **p<0.01, *p<0.05 vs. control (Ctr).
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Source Image file from Tarassishin L, Casper D, Lee S (2014). "Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas". PLOS ONE. DOI:10.1371/journal.pone.0103432. PMID 25054228. PMC: 4108401.
Author Tarassishin L, Casper D, Lee S
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current02:42, 25 July 2014Thumbnail for version as of 02:42, 25 July 2014688 × 568 (70 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0103432

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