File:A conserved developmental mode emerges upon removal of species-specific extraembryonic environments.jpg
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A conserved developmental mode emerges upon removal of species-specific extraembryonic environments. The developmental trajectories which aggregates of ESC(-LP)s exhibit upon removal of external or extraembryonic and associated boundaries may constitute a conserved mode that is shared across species. On a cellular level, this can be visually approximated as cells undergoing differentiation within Waddington’s developmental landscape Waddington, 1957. The landscape is shaped by key gene networks which remain constant between species and in vitro (bottom) as well as the external (micro-)environment and embryo geometry (top), here represented as green tiles, which vary between species. In case the latter factors are not present as ESCs are removed from their native context and grown in vitro, cellular developmental trajectories revert to the aforementioned conserved mode since cells from different species now experience the same landscape. ESC: embryonic stem cells. |
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| Source | https://iiif.elifesciences.org/lax/69066%2Felife-69066-fig3-v1.tif/full/1500,/0/default.jpg https://doi.org/10.7554/eLife.69066 (2021) Studying evolution of the primary body axis in vivo and in vitro eLife 10:e69066. |
| Author | Kerim Anlas Vikas Trivedi |
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© 2021, Anlas and Trivedi
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| current | 10:02, 26 April 2024 | | 1,500 × 815 (216 KB) | Rasbak (talk | contribs) | {{Information |description=A conserved developmental mode emerges upon removal of species-specific extraembryonic environments. The developmental trajectories which aggregates of ESC(-LP)s exhibit upon removal of external or extraembryonic and associated boundaries may constitute a conserved mode that is shared across species. On a cellular level, this can be visually approximated as cells undergoing differentiation within Waddington’s developmental landscape Waddington, 1957. The landscape... |
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