File:A. M. A. archives of neurology and psychiatry (1919) (14780114945).jpg

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Types of altered ganglion cells in the invaded area. The periphery of the cell in the center contains a number of cancer cells; the central portion has numerous granules (Abbaustoffe) and several vacuoles containing lymphocytes and polymorphonuclear cells (use hand lens). At A, there is another ganglion of smaller size filled with cancer elements; at B, a dark homogeneous cell without inclusions: at C, a new formed capillary; at D, a fibroblast; the numerous round, pale bodies with distinct nucleoli are cancer cells. Thionin, x480

Identifier: amaarchivesofneu08ameruoft (find matches)
Title: A. M. A. archives of neurology & psychiatry
Year: 1919 (1910s)
Authors: American Medical Association
Subjects: Neurology Psychiatry
Publisher: (Chicago) American Medical Association
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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be unrecognizable without further study. As a rule, the cellswere large, some truly gigantic (Fig. 2). larger than those to be foundin any other central nerve lesion, not excepting amaurotic familyidiocy. They were round or irregular in shape, usually pale, somedarkly stained, homogeneous or finely granular, devoid of any trace ofNissls bodies, and the processes were more or less comjiletely obliterated. H ASS/.X-SIXCER—CEREBRAL CARCIXOMA 159 The nucleus was swollen, pale and eccentric, the chromatin broken up,but the membrane and nucleolus almost always intact. Sometimes thenucleus stained so faintly that it could be detected only by the presenceof the nucleolus. Many of the ganglion cells were vacuolated, othersbroken up or unevenly stained. With the Bielschowsky silver impreg-nation some showed a reticulum but. as a rule, the neurofibrils wereabsent. The majority of the ganglion cells showed inclusions: granulesscattered through the (jrotoplasm. vacuoles containing pol\-mor))ho-
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pig. 3.—Types of altered ganglion cells in the invaded area. The peripheryof the cell in the center contains a number of cancer cells; the central portionhas numerous granules (.Abbaustoffe) and several vacuoles containing lympho-cytes and polymorphonuclear cells (use hand lens). At A, there is anotherganglion of smaller size filled with cancer elements; at B, a dark homogeneouscell without inclusions: at C, a new formed capillary; at D, a fibroblast; thenumerous round, pale bodies with distinct nucleoli are cancer cells. Thionin-X480. nuclear or mononuclear leukocytes and—of especial interest—cancercells. In some instances these last occupied the entire ganglion cellbody, including the processes ( Fig. 2) ; in others thev were collected 160 JhCHirES Of .\ EURO LOGY ASD FSVCHIATRY in a dense cluster in the center or in a crescentic mass at the peripheryof the cell (Fig. 3). With scarlet red, Marchi and lichtgriin-fuchsin stains minute fat-granules were demonstrable in the gangli

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