File:A. M. A. archives of neurology and psychiatry (1919) (14593872210).jpg

Identifier: amaarchivesofneu08ameruoft (find matches)
Title: A. M. A. archives of neurology & psychiatry
Year: 1919 (1910s)
Authors: American Medical Association
Subjects: Neurology Psychiatry
Publisher: (Chicago) American Medical Association
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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many investigators have alwaysfailed to obtain results by such injections. Jahnel himself thought hesucceeded with one rabbit after seven months of incubation, but hecould not keep the strain to study its characteristics. Aalente failedutterly in 103 animals, using puncture material from brains of living 598 ARC I IIIUS OF XEUROLOGV AM) PSVCIUATRY patients with general jjaralysis, also the blood and si)inal fluid. Tfjrsterand Thomasczewski likewise failed in sixty rabbits, with brain puncturematerial obtained from fifty-three living jjatients with general paralysis.If the aj)parently successful injections can be trusted, we mustassume that, at least sometimes, spirochetes are present in the blood andspinal fluid in general ))aralysis, but whether the blood and fluid play anessential role in spreading them is still doubtful. The undecided ques-tion always rises in these cases as to whether the ordinary lesions ofsomatic syphilis coexist with the specific lesions of general paraly.sis.
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Fig. 9.—Spirochetes in the vessels and in the nervous tissue.Figures 9 and 10 are photographic reproductions from Plate 3, Figures 11and 12, in Jahnels article. RELATION OF SPIROCHETES IN GENERAL PARALYSIS TOWASSERMANN REACTION Sioli reports one case of general paralysis which showed spirochetesin the brain although the Wassermann reaction (twice repeated) wasnegative in both blood and spinal fluid. \ alente, a Portuguese investi-gator, reports three cases with positive spirochete findings but negativeWassermann reactions in the spinal fluid. In my experience I can recallno case of general paralysis, confirmed by the microscope, in whichthe fluid Wassermann test, if made, was consistently negative. Jahnelregards a positive Wassermann reaction as a probable index of thepresence of spirochetes in the body. I think we should look on the DUXLAP—GEXERAL PARALYSIS 599 negative Wassermann reactions (not further described especially as totreatment) with some skepticism, as defects in tech

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