File:42003 2020 1088 Fig1 HTML.webp
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English: Molecular drivers of SARS-CoV-2 productive infection. ACE2 and TMPRSS2 are co-expressed on ciliated bronchial epithelial cells and type II pneumocytes and the epithelia of small intestine thus making these potential organ sites and routes for SARS-CoV-2 infection. The virus utilizes the Spike glycoprotein (S) to attach to the host cell and trigger fusion events between the virus and host lipid bilayers. Host ACE2 and TMPRSS2 are critical mediators of this process. The virus is then internalized through receptor-mediated endocytosis, or via clathrin-mediated pathways or through lipid rafts at the plasma membrane. Once inside the host cytoplasm, the viruses release their genomes to allow replication of their genetic material. Encapsulated viral-like particles with RNA genomes arise in the ERGIC complex before they erupt as mature virus. |
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Chakravarty, D., Nair, S.S., Hammouda, N. et al. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Commun Biol 3, 374 (2020). https://doi.org/10.1038/s42003-020-1088-9 |
| Author | Dimple Chakravarty, Sujit S. Nair, Nada Hammouda, Parita Ratnani, Yasmine Gharib, Vinayak Wagaskar, Nihal Mohamed, Dara Lundon, Zachary Dovey, Natasha Kyprianou, and Ashutosh K. Tewari |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 12:46, 30 January 2021 | | 1,495 × 1,050 (149 KB) | Guest2625 (talk | contribs) | Uploaded a work by Dimple Chakravarty, Sujit S. Nair, Nada Hammouda, Parita Ratnani, Yasmine Gharib, Vinayak Wagaskar, Nihal Mohamed, Dara Lundon, Zachary Dovey, Natasha Kyprianou, and Ashutosh K. Tewari from Chakravarty, D., Nair, S.S., Hammouda, N. et al. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Commun Biol 3, 374 (2020). https://doi.org/10.1038/s42003-020-1088-9 with UploadWizard |
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