File:41591 2023 2429 Fig7 ESM.webp

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English: "The proportion of phenotypic variance explained by the polygenic score predicting coronary artery disease (CAD) was calculated in the UK Biobank European ancestry validation cohort for each GPS score using the A: Nagelkerke’s pseudo-R2 metric, as the difference of the full model inclusive of the polygenic score plus age, sex, genotyping array, and the first ten principal components of ancestry minus R2 for the covariates alone; and B: logit-liability R2 metric. GPS2018 denotes previously published polygenic score for CAD9. > 3-fold larger CAD GWAS designates metrics for polygenic score generated using summary statistics from the most recent Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics consortium analysis (CARDIOGRAMplusC4D) excluding the UK Biobank. Multi-ancestry CAD GWAS refers to the polygenic score generated by combining ancestry-specific polygenic scores generated using discovery data from Genes & Health, Biobank Japan, Million Veteran Program, FinnGen, and CARDIOGRAMplusC4D (excluding UK Biobank). GPSMult designates polygenic score for CAD designed with summary statistics from multiple ancestries and multiple CAD-related traits."
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Source https://doi.org/10.1038/s41591-023-02429-x
Author Analysis of data by A.P.P., M.W., Y.R., S.K., S.L.C., X.Y., C.T., S.A., A.C.F., D.A.v.H., A.S.B., K.G.A., P.N. and A.V.K.

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current06:12, 11 August 2023Thumbnail for version as of 06:12, 11 August 20232,161 × 746 (61 KB)Chamaemelum (talk | contribs)Uploaded a work by Analysis of data by A.P.P., M.W., Y.R., S.K., S.L.C., X.Y., C.T., S.A., A.C.F., D.A.v.H., A.S.B., K.G.A., P.N. and A.V.K. from https://doi.org/10.1038/s41591-023-02429-x with UploadWizard

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