File:41591 2023 2429 Fig11 ESM.webp
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Captions
A large polygenic score percentile range is as good as disease risk factors for CAD
Summary
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| Description |
English: "A: Cumulative incidence of coronary artery disease (CAD) events (%) over length of follow-up stratified by presence of prior peripheral artery disease (PAD) or no prior PAD with GPSMult in the middle quintile or top 8% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset. B: Cumulative incidence of CAD events (%) over length of follow-up stratified by presence of prior diabetes mellitus (DM) or no prior DM with GPSMult in the middle quintile or top 21% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset. C: Cumulative incidence of CAD events (%) over length of follow-up stratified by presence of prior severe hypercholesterolemia (estimated untreated low-density lipoprotein cholesterol, LDL-C 190 mg/dL or higher), or no prior hypercholesterolemia with GPSMult in the middle quintile or top 28% of the population, estimated using Cox proportional-hazards regression model adjusted for age, sex, genotyping array, and the first ten principal components of ancestry in the European ancestry UK Biobank validation dataset." |
| Date | |
| Source | https://doi.org/10.1038/s41591-023-02429-x |
| Author | Analysis of data by A.P.P., M.W., Y.R., S.K., S.L.C., X.Y., C.T., S.A., A.C.F., D.A.v.H., A.S.B., K.G.A., P.N. and A.V.K. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 06:12, 11 August 2023 | | 2,161 × 735 (98 KB) | Chamaemelum (talk | contribs) | Uploaded a work by Analysis of data by A.P.P., M.W., Y.R., S.K., S.L.C., X.Y., C.T., S.A., A.C.F., D.A.v.H., A.S.B., K.G.A., P.N. and A.V.K. from https://doi.org/10.1038/s41591-023-02429-x with UploadWizard |
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