File:41523 2021 265 Fig1 HTML-Photoroom.webp
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Captions
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tucatinib
Summary
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| Description |
English: There are four members of the HER2 receptor family, these are the targets of lapatinib, neratinib, pyrotinib and tucatinib. The HER2 extracellular domain has no known ligand and is activated by the formation of homo or heterodimers (exemplified by a HER2-HER3 heterodimer in the figure). These dimers lead to phosphorylation of tyrosine kinase residues in the cytoplasmic domain which function as docking sites for proteins that activate the PI3K and MAPK signaling pathways downstream leading to cell cycle progression and proliferation. |
| Date | |
| Source | https://www.nature.com/articles/s41523-021-00265-1 |
| Author | Ilana Schlam & Sandra M. Swain |
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| current | 20:18, 26 April 2024 | | 685 × 651 (17 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Ilana Schlam & Sandra M. Swain from https://www.nature.com/articles/s41523-021-00265-1 with UploadWizard |
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