File:41413 2018 21 Fig1 HTML.jpg
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41413_2018_21_Fig1_HTML.jpg (781 × 448 pixels, file size: 278 KB, MIME type: image/jpeg)
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[edit]Description41413 2018 21 Fig1 HTML.jpg |
English: Existing paradigm for long bone endochondral ossification. a Primary endochondral ossification begins with the formation of a chondrocyte template during embryogenesis. Chondrocytes undergo hypertrophy beginning from the mid-diaphysis, eventually extending to the epiphyseal poles. Vasculature invades the forming bone, transporting marrow, mesenchymal stromal cells, and osteoclasts. Hypertrophic cells undergo apoptosis, aided by the removal of matrix by osteoclasts. Mesenchymal stromal cells differentiate into osteoblasts and then osteocytes. b Secondary ossification occurs at the epiphysis post-natally in rodents. Immature chondrocytes at the center of the epiphysis become hypertrophic to produce mineralized collagen and eventually undergo apoptosis. Vasculature invades and transports marrow, mesenchymal stromal cells, and osteoclast precursors. Bone formation initiates at the center and extends peripherally. |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002476/ |
Author | Patrick Aghajanian and Subburaman Mohan |
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current | 09:35, 31 January 2024 | 781 × 448 (278 KB) | PecMo (talk | contribs) | Uploaded a work by Patrick Aghajanian and Subburaman Mohan from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002476/ with UploadWizard |
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Width | 3,906 px |
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Height | 2,242 px |
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Compression scheme | LZW |
Pixel composition | RGB |
Orientation | Normal |
Number of components | 3 |
Horizontal resolution | 300 dpi |
Vertical resolution | 300 dpi |
Data arrangement | chunky format |
Software used | Adobe Photoshop CS4 Windows |
File change date and time | 20:05, 24 May 2018 |
Color space | sRGB |
Image width | 1,953 px |
Image height | 1,121 px |
Date and time of digitizing | 20:40, 24 May 2018 |
Date metadata was last modified | 01:35, 25 May 2018 |
Unique ID of original document | xmp.did:2D8524ED3A5FE811A58DB9BAB4509AE2 |
IIM version | 20,028 |
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