File:41408 2021 467 Fig2 HTML.webp
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41408_2021_467_Fig2_HTML.webp (685 × 522 pixels, file size: 52 KB, MIME type: image/webp)
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[edit]Description41408 2021 467 Fig2 HTML.webp |
English: Ibrutinib (IBR) leads to CLL cell mobilization from the nodal compartment, making CLL cells more accessible to chemotherapy and anti-CD20 antibody in peripheral blood. Lower left diagram depicts intracellular mechanism of combination. Anti-CD20 antibody along with chemotherapy induces apoptosis and immunologic cell death, while ibrutinib affects proliferation, survival, and migration of B cells. Chemotherapeutic agents such as fludarabine are well known to cause depletion of all T cell subsets, thereby reducing negative trophic signals between T cells and CLL cells. This figure was created with BioRender.com. BCR, B cell receptor. |
Date | |
Source | https://www.nature.com/articles/s41408-021-00467-7 |
Author | Natalia Timofeeva & Varsha Gandhi |
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current | 22:49, 15 January 2024 | 685 × 522 (52 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Natalia Timofeeva & Varsha Gandhi from https://www.nature.com/articles/s41408-021-00467-7 with UploadWizard |
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