File:41392 2022 1042 Fig2 HTML.webp
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41392_2022_1042_Fig2_HTML.webp (685 × 523 pixels, file size: 51 KB, MIME type: image/webp)
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[edit]Description41392 2022 1042 Fig2 HTML.webp |
English: AR signaling pathway and targeted therapeutic approaches in PCa. Androgen synthesis is regulated by the hypothalamic–pituitary–gonadal axis. When androgens such as testosterone (T) and DHT bind to AR, AR releases itself from the heat shock protein complex, translocates into the nucleus, and promotes gene transcription to accelerate tumor progression. Targeting the androgen-signaling axis includes multiple approaches, such as targeting GnRH to prevent luteinizing hormone release, targeting CYP17A1 to restrain androgen synthesis, or directly targeting AR to inhibit AR transcription activity |
Date | |
Source | https://www.nature.com/articles/s41392-022-01042-7 |
Author | Yundong He, Weidong Xu, Yu-Tian Xiao, Haojie Huang, Di Gu & Shancheng Ren |
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current | 21:08, 14 February 2024 | 685 × 523 (51 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Yundong He, Weidong Xu, Yu-Tian Xiao, Haojie Huang, Di Gu & Shancheng Ren from https://www.nature.com/articles/s41392-022-01042-7 with UploadWizard |
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