File:13045 2009 Article 63 Fig2 HTML.webp
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lenalidomide
Summary
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| Description |
English: T cell activation. B7-CD28 co-stimulation pathway is needed for T cell activation and CTLA4 Ig blocks this pathway leading to T cell inactivation. Lenalidomide acts by directly inducing tyrosine phosphorylation of CD28 on T cells leading to activation of downstream targets such as PI3K, GRB-2-OS, and NF-κb, thus partially overcoming CTLA4 Ig blockade and leading to T cell clonal proliferation. |
| Date | |
| Source | https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-2-36 |
| Author | Venumadhav Kotla, Swati Goel, Sangeeta Nischal, Christoph Heuck, Kumar Vivek, Bhaskar Das & Amit Verma |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 19:59, 9 June 2024 | | 685 × 535 (48 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Venumadhav Kotla, Swati Goel, Sangeeta Nischal, Christoph Heuck, Kumar Vivek, Bhaskar Das & Amit Verma from https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-2-36 with UploadWizard |
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